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A Review of Synthetic Approaches and Biological Activity of Substituted Hydrazones

Jaweria Ambreen1 , Hassan M. Khachfe2 and Nadeem Kizilbash1

Hydrazone derivatives are used extensively in organic synthesis. The reactive parts of these molecules are the carbon and nitrogen atoms. Hydrazones are used to synthesize heterocyclic compounds possessing biological activities. They exhibit cardio-protective, antioxidant, anti-inflammatory, anti-convulsant, anti-microbial, anti-cancer, anti-protozoan, anti-parasitic, anti-platelet, anti-helminthic, anti-diabetic, anti-tubercular and anti-HIV properties. In recent years, there have been numerous developments in this field and many new aspects of hydrazone chemistry and applications have been developed.