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Adenosine deaminase and dipeptidyl peptidase- IV activities in cancerous and non cancerous human colon and gastric tissues

Zahide Esra Durak, Suleyman B�?�?�?�?�?�?�?¼ber, Ender ilmi Kocao�?�?�?�?�?�?�?°lu, Bahad�?�?�?�?�?�?�?½r �?�?�?�?�?�?�?�?zt�?�?�?�?�?�?�?¼rk

It is aimed to investigate activity changes in dipeptidyl peptidase-4 (DPP-4) and adenosine deaminase (ADA) enzymes in cancerous and noncancerous human gastric and colon tissues. Thirty two cancerous and 32 non cancerous adjacent gastric tissues removed frompatients with gastric cancer, and 18 cancerous and 18 non cancerous colon tissues from patients with colon cancer were used in the studies. In the tissues, DPP-4 andADA activities were measured. DPP-4 activities were found to increase significantly in cancerous tissues relative to non cancerous ones (0.073±0.169 vs. 3.86±3.41, p<0.001 for colon and 1.25±0.95 vs. 2.52±1.05, p<0.05 for gastric tissue). In the ADA activities, there were however no differences be-tween cancerous and non cancerous tissues for both cancers. In the correlation analysis performed betweenDPP- 4 andADAactivities,weak correlations were observed. It has been established that DPP-4 is significantly increased, butADAis not changed in the cancerous tissues. It has been suggested that the increase in DPP-4 activity in the cancerous tissues might be of importance in the progress of cancer process, and that inhibitors ofDPP-4 enzymesmight give helpful results in this regard.