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Ameliorate the effect of Solanum trilobatum L. on hepatic enzymes in experimental diabetes

Ganesan Kumar, Gani Sharmila Banu, Kartheek R.Balapala

This paper deals with oral administration of leaves extract of Solanum trilobatum L. on blood glucose and plasma antioxidant status in streptozotocin (STZ) diabetic rats. The study was undertaken to evaluate hepatic enzymes in experimental diabetes. Oral administration of aqueous extract (100, 200mg/kg) in STZ diabetic rats increased hepatic hexokinase activity and decreased hepatic glucose-6-phosphatase, serum acid phosphatase (ACP), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). The Solanum trilobatum leaves extract is hypoglycemic, hepatoprotective and is able to ameliorate biochemical damages in STZ induced diabetic rats.