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Anovel synthesis and antimicrobial activity of new coumarin derivatives

K.Narasimha Sarma, M.C.S.Subha, K.Chowdoji Rao


A series of new coumarine derivatives (6a-h) were synthesized from N-(6- bromo-2-oxo-2H-chromen-3-yl) acetamide (1). The synthetic stages involved condensation of phenylboronic acid (2)withN-(6-bromo-2-oxo-2Hchromen- 3-yl)acetamide (1) (Suzuki coupling) yielded N-(2-oxo-6-phenyl- 2H-chromen-3-yl)acetamide (3a-c) followed by the deportation in presence of base (or) acid media gives 3-amino-6-phenyl-2H-chromen-2-one (4a-c), finally compound (4a-c) coupling with theAdehydes to get coumarine derivatives of Schiff-bases (6a-h) and characterized through IR, 1H-NMR, 13CNMR, Mass spectral data and elemental analysis. The synthesized compounds (6a-h) have been screened for antimicrobial activity.


索引于

  • 中国社会科学院
  • 谷歌学术
  • 打开 J 门
  • 中国知网(CNKI)
  • 引用因子
  • 宇宙IF
  • 研究期刊索引目录 (DRJI)
  • 秘密搜索引擎实验室
  • ICMJE

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