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Antioxidant, analgesic and anti-inflammatory activities of Leucas Cephalotes (Roxb.ex Roth) Spreng

B.Baburao, A.Rama Narsimha Reddy, H.Parameshwar, Y.Narsimha Reddy, B.Ravi Kumar, G.Krishna Mohan

The whole plant of the methanolic extract from Leucas Cephalotes was screened for in vitro antioxidant (using DPPH method), analgesic (using hot plate test in mice) and anti-inflammatory (using rat paw edema test) activity at the doses of 200 and 400mg/kg. Themethanolic extract of Leucas Cephalotes (MELC) has scavenged the DPPH radicals in a dose dependent manner. The IC50 value to scavenge DPPH radicals was found to be 427.3µg/ml. A significant (p<0.0005) analgesic activity was observed at 60 min with 200 mg/kg and 400 mg/kg has exhibited maximum activity. The maximum anti-inflammatory response was produced at 3 hr and 2 hr with doses of 200 and 400 mg/kg respectively. These results suggest that the methanolic extract Leucas Cephalotes has exhibited significant analgesic and anti-inflammatory effects, whichwere comparablewith standard drugs.