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Assay of tenofovir disproxil fumarate in bulk and its marketed formulations by visible spectrophotometry

Kalyana Ramu Buridi


A simple and sensitive visible spectrophotometric method for the determination of tenofovir disproxil fumarate using 3-methyl-2- benzothiazolinone hydrazone hydrochloride (MBTH) reagent has been developed in bulk and tablet dosage forms. It is based on the formation of intense blue colored species by treating the drug with MBTH reagent in the presence of ferric chloride with an absorptionmaximumof 631nm. The Regression analysis of BeerÂ’s Law plot showed good correlation in a general concentration range of 10-30µg/ml. The proposed method is validated with respect to accuracy, precision, linearity and limit of detection. The suggested procedure is successfully applied to the determination of the drug in pharmaceutical preparation, with high percentage of recovery, good accuracy and precision. The results of analysis have been validated statistically by repeatability and recovery studies. The results are found satisfactory and reproducible. The method is applied successfully for the estimation of tenofovir disproxil fumarate in tablet dosage form without the interference of excipients.


索引于

  • 中国社会科学院
  • 谷歌学术
  • 打开 J 门
  • 中国知网(CNKI)
  • 引用因子
  • 宇宙IF
  • 电子期刊图书馆
  • 研究期刊索引目录 (DRJI)
  • 秘密搜索引擎实验室
  • ICMJE

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