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Detection and spectrophotometric determination of paracetamol using NBS

G.V.S.R.Pavan Kumar, V.Rama Devi, K.V.Divya Lakshmi, I.Ramya, B.Sreerama Murty

simple and accurate spectrophotometric method has been developed by the authors for the detection and determination of paracetamol in pharmaceutical formulations in the formof tablets. Paracetamol, after dissolving in 4M sulphuric acid treated with 1% aqueous N-bromo succinamide (NBS) solution, exhibits a stable bluish violet colour. The coloured compound shows a ëmax at 560 nm. The method also recommended as a spot test for paracetamol. It is precise and found to be accurate for qualitative and quantitative determinations of paracetamol.