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Determination of Consecutive Stability Constant of Binary Complex of Mn (II) with Antibiotic Tetracycline Hydrochloride by Polarographic Method

Bhavna A. Shah, Ami R. Bhatt and Ajay V. Shah

Polarographic measurements have been used to determine the consecutive stability constants of binary complex of Mn (II) with antibiotic tetracycline hydrochloride (TC) at temperature 25 ± 2°C, in presence of 1.0 M KCl as supporting electrolyte and 0.1% gelatin as a maxima suppressor in an inert nitrogen atmosphere. Polarograms of Mn (II) - TC system at pH 7.3 ± 0.1 in aqueous medium has been used to study the complex stoichiometry. The DeFord-Hume’s method was applied for the analysis of polarographic waves arising from ion transfer reactions at DME interface and the successive stability constants of this system have been evaluated. The cathodic shift in E½ coupled with decrease in diffusion current with increasing ligand concentration is observed during the experimental work.