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Determination of inorganic anions in proton pump inhibitors using ion chromatograph

D.Koti Reddy, Anil Gopala, M.R.P.Reddy, D.Rambabu, K.Mukkanti

Ion chromatography (IC) was used to determine the inorganic anions (fluoride, chloride, bromide, nitrate, sulphate and phosphate) in rabeprazole sodium, pantaprazole sodium and omeprazole sodium (Proton Pump Inhibitors). In the absence of matrix standards, the separation efficiency has been investigated by spiking samples with varying amounts of anionic standards, spike recoveries were between (102 to 120 %). It was observed that the sample organic matrix strongly interferes and increases the conductance of monovalent anions upto 20%.