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Development and quantification of Ethyl-p-toluene sulfonate and Isopropyl-p-toluene sulfonate at genotoxic level in tenofovir disoproxil fumarate by using advanced technique

Nalavade Atul Kakasaheb, B.Sandhyakumari, K.Ramakrishna, V.Srinivasarao


AsensitiveGC-MSmethodwas developed and validated for the content of Ethyl-p-toluene sulfonate and Isopropyl-p-toluene sulfonate in Tenofovir Disoproxil Fumarate byGCMS.RXI-1ms columnwas selectedwith electron impact ionization technique, Quadrupole mass analyzer.Method is sensitive, precise, accurate and linear as per the parameters conducted for the validation activity. Calibration curve showed good linearity over the concentration range LOQ to 150% of the evaluation level. Limit of detection and Limit of Quantification for Ethyl-p-toluene sulfonate is 0.15µg/g (0.006µg/mL) and 0.45µg/g (0.019µg/mL) respectively. Limit of detection and Limit of Quantification for Isopropyl-p-toluene sulfonate is 0.21µg/g (0.008µg/mL) and 0.65µg/g (0.026µg/mL) respectively. Also method is evaluated for accuracy at 50 to 150%of the evaluation limit.


索引于

  • 中国社会科学院
  • 谷歌学术
  • 打开 J 门
  • 中国知网(CNKI)
  • 引用因子
  • 宇宙IF
  • 电子期刊图书馆
  • 研究期刊索引目录 (DRJI)
  • 秘密搜索引擎实验室
  • ICMJE

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