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Development and validation of spectrophotometric method forestimation of troxipide in tablet dosage form.

Shailendra P.Kela, Somnath A.Patil, Alok Kumar Pandey, Deepak Kumar Dash.

Two simple, precise and economical spectroscopic methods have been developed for the estimation of Troxipide in bulk and pharmaceutical formulation. Method A is first order derivative spectroscopy where drug showed absorbancemaxima 247.58 nm.Amplitude difference (dA/dë) was calculated and plotted against concentration and regression equation was calculated. Method B applied wasAUC (Area under curve) in which area in thewavelength range of 255-265 nmwas selected for analysis ofTroxipide. Drug followed the Beer-LambertÂ’s law in the concentration range of 10-50 µg/ml (r2=0.999) in 0.1 N HCl for both the methods. The % assay of marketed formulation for first order derivative and area under curve method was found to be 98.45% and 99.32% respectively. The methods were validated with respect to linearity, precision and accuracy studies. Recovery studies for first order derivative and area under curve method was found to be satisfactory. The methods were found to be simple, precise and accurate and can be employed for routine quality control analysis of Troxipide in bulk as well as its dosage form. 2013 Trade Science Inc. - INDIA.