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Development and validation of spectroscopic method for estimation of valacyclovir in tablet dosage form

Girija B.Bhavar, Seema A.Gosavi, Pallawi B.Shewale, Mangesh A.Shinde

A simple, rapid and sensitive method has been developed for the quantitative estimation of valacyclovir hydrochloride in bulk and in tablets. The wavelength 251.40 nm was selected for the estimation of drug using distilled water as a solvent. The drug obeyed Beer-LambertÂ’s law over the concentration range 1-25 ìg/ml. the accuracy of the method was assessed by recovery studies and was found between 99.58 - 100.17 %. The method was statistically validated for the linearity, precision, accuracy, LOD, LOQ and ruggedness. The method was successfully applied for routine analysis of this drug in bulk and formulation.