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Formulation and characterization of starch nanoparticles for controlled release of doxorubicin

Siva Samraj Raveendran, Nagaraj Subramani, ShiekAbdul Rahman, Sasikumar Palsamy

Nanoparticles synthesised from starch provides enhanced solubility of Doxorubicin in the aqueous solution. Various parameters like presence of organic solvent, surfactant concentration, loading efficiency, doxorubicin concentration affects the size of doxorubicin-starch nanoparticle. Under controlled conditions, doxorubicin loaded in situ on to the starch polymer with particle size ranging between 10nm to 100nm was achieved by nanoprecipitation method. These nanoparticles were characterized under Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR) to find the surface topology, particle size, drug loaded inside the polymer, structure of DOX-starch nanoparticles. The doxorubicin loaded starch nanoparticle was observed for in vitro drug release study in a buffer solution mainly phosphate buffer solution for 5- 7 days. This reveals that the starch polymer acts as an efficient carrier vehicle for the anticancer agents.