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Formulation and Evaluation of Hydrodynamically Balanced Floating Tablets of Antidiabetic Agent

A. Shiva Lakshmaiah, Rajesh Akki, D. Nagarjuna Reddy, V. Vasu Naik, A. Anka Rao, Amjad Pasha and Sanjay Kumar Gupta

The objective of the present study was to develop a hydrodynamically balanced system of metformin as a single unit floating tablet. Various grades of low-density polymers such as HPMC K4M, HPMC K 15M and Polyethylene oxide were used in different concentrations along with gas generating agent sodium bicarbonate and tablets were prepared by using direct compression technique to study the effect these polymers on floating behaviors. The physicochemical properties of different formulations, their buoyancy lag time and total floatation time and swelling index were evaluated. It is found that the high viscosity grade polymers given better controlled release drug profile. The in vitro release studies indicated that the floating dosage forms containing (P3) polyethylene oxide polymer showed good drug release rate up to 12hrs in comparison to other batches. The results indicated that hydrodynamically balanced tablets of Metformin containing polyethylene oxide provides a better option for sustained release action