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FORMULATION AND EVALUATION OF TOPICAL DRUG DELIVERY SYSTEM CONTAINING CLOBETASOL PROPIONATE NIOSOMES

M. ABRAHAM LINGAN, A. ABDUL HASAN SATHALI, M. R. VIJAYA KUMAR and A. GOKILA

The aim of the present study was to formulate topical gel containing clobetasol propionate niosomes to prolong the duration of action and prevent its side effects. The clobetasol propionate niosomes were prepared by altering the ratios between various non-ionic surfactants (Span 40, 60, 80) and cholesterol by three methods such as thin film hydration method, ether injection method and hand shaking method. The prepared niosomes were subjected to drug content analysis, entrapment efficiency, size analysis and invitro drug release studies. The higher entrapment efficiency (91.37%) was obtained with Span 60 niosomes (ratio of surfactant, cholesterol- 1 : 0.5) prepared by thin film hydration method was evaluated for its stability and formulated as gel formulation. The prepared niosomal gel (G2) and marketed gel (G3) were subjected to drug content analysis, in vitro drug release studies and in vivo pharmacodynamic studies. Our results suggested that the niosomal delivery of clobetasol propionate in carbopol gel base acts as a suitable topical drug delivery system to prolong the duration of action.