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IN VITRO ANTHELMINTIC ACTIVITY OF LEAVES OF JUGLANS REGIA L AGAINST PHERETIMA POSTHUMA

R. DAS, D. K. MEHTA and A. GUPTA

Among the most common infections of digestive system in human beings are helminth infections. In developing countries they pose a large threat to the society. Such parasitic diseases cause severe morbidity, including lymphatic filariasis, onchoserciasis and schistosomiasis. Present study is an attempt to evaluate anthelmintic activity of different extracts of Juglans regia L leaf.
Many traditional plants and herbs are reported to have anthelmintic activity. Juglans regia L the valuable species from Juglandaceae family has a long history of traditional use as an anthelmintic. All parts of the plant are a rich source of medicinally useful components. Present study is an attempt to evaluate anthelmintic activity of different extracts of leaves of J. regia L. Different extracts of the plant material were tested against adult Indian earthworms Pheretima posthuma (Pheritimidae) as test worms. The bioassay involved determination of the time of paralysis and time of death control. Piperazine citrate (10 mg/mL) was used as standard reference drug.
The results of this study strongly support the traditional anthelmintic use of the plant material.