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Method development and validation of menthol in cough syrup by gas chromatography

Ravi Kalgutkar, K.Ramakrishna, V.Srinivasarao

A precise gas chromatographic method has been developed for the determination of menthol content in cough syrup. In thisMethodDB-1 columnwith (30mx0.32mmx1.0µm) and nitrogen as a carrier gas at a flow rate of 1.0 ml/ minwas used. The oven temperaturewas programmed at 100°C for 2 min and 10°C rise up to 240°C (Hold for 25min). The injector port and detector port temperature ismaintained at 240°C and 260°C. Detection was carried out by FID detector. In this method methanol was used as diluent. The results of recovery studies were statistically evaluated for its method precision and accuracy study. The gas chromatography method is less expensive and gives an accurate and precise result.