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Microwave assisted synthesis and biological evaluation of 3-aryl-5-(thiophen-3-ylmethyl)-1H-1, 2, 4-triazoles

V.V.Patil, P.J.Chaudhari

In this present work, microwave assisted synthesis of 3-aryl-5-(thiophen-3- ylmethyl)-1H-1, 2, 4-triazoleswere carried out.(3a-i) newcompounds were synthesized by reactions of 2-(thiophen-3-yl) acetohydrazide and various aromatic nitriles. The synthesized derivativeswere characterized by spectral studies and also byC, H,N analyses. Synthesized derivativeswere screened for their anti-inflammatory activity by, the rat paw edema test method and analgesic activity by the tail flickmethod. The compounds (3b, 3d, 3g) and (3i) showed remarkable reduction in rat pawedema induced by carrageenan treatment. The compounds (3b, 3d, 3g,) and (3i) showed good analgesic activity.