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Microwave Assisted Synthesis and in vitro Antimicrobial Study of a New Mannich Base, N-(1-Piperidinosalicylyl) Acetamide

S. Priya, D. Sathya, J. Senthil Kumaran, N. Jayachandramani, S. Mahalakshmi and Amali Roseline Emelda

The synthesis of a new Mannich base, N-(1-piperidinosalicylyl) acetamide, has been carried out under the microwave condition. The structure of the compound was established by spectral analysis and tested for antimicrobial activity against Gram positive bacteria, i.e. Staphylococcus aureus, Bacillus subtilis and Gram negative bacteria, i.e. Proteus vulgaris and antifungal activity against Candida albicans. Tetracycline was used as standard for antibacterial activity and amphotericin for antifungal activity. The compound has shown maximum activity against both Gram positive and Gram negative bacteria.