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New Active Bisphosphonate (Etidronate) Complexes as Anticancer Agents

Fathy AA1, Butler IS2, Elrahman MA3 and Mostafa SI1


Bisphosphonates (Bps; have P-C-P moieties) are drugs that slow down or prevent bone loss. They inhibit osteoclasts, responsible for bone resorption, and allow osteoblasts, bone building cells, to be more effective; i.e., improve bone mass. Moreover, Bps are considered as anticancer drugs that cause bone damage. New complexes of etidronate disodium (Na2Etd) with Pd (II) and Pt (II) were synthesized and characterized based on elemental analysis, molar conductivity, thermal and spectral (IR, NMR, UV-visible, mass) measurements. Their anticancer activity was tested against human prostate (DU 145) and breast (MDA-MB231) cancer cell lines compared to Cisplatin, the market drug.


索引于

  • 中国社会科学院
  • 谷歌学术
  • 打开 J 门
  • 中国知网(CNKI)
  • 引用因子
  • 宇宙IF
  • 电子期刊图书馆
  • 研究期刊索引目录 (DRJI)
  • 秘密搜索引擎实验室
  • ICMJE

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