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Novel spectrophotometric techniques for determination of trazodone hydrochloride in bulk powder and pharmaceutical formulation

A.E.El-Gindy, M.Farouk, O.Abd El-Aziz, E.A.Abdullah


Three simple novel spectrophotometric methods were established for the analysis of Trazodone (TRZ). The proposed methods are stability indicating for determination of Trazodone in presence of its degradation products, obtained by stressing Trazodone by alkali and hydrogen peroxide in presence of heat, respectively. The adopted zero-crossing derivative, derivative ratio and pH-induced difference spectrophotometric techniques were proved to be sensitive and accurate, where the accuracy of the assay was evaluated using the standard deviation coefficient of variation which were found to be within the acceptable limit of 2% and were specifically 0.761&0.598%,0.389&0.341%and 0.738&0.406%for intradayand interday samples, respectively. All the proposed methods were validated according to the International Conference on Harmonization (ICH) guidelines reference and successfully applied for determination of Trazodone Hydrochloride in pure form, in laboratory prepared mixtures and in pharmaceutical formulation. The obtained results were statistically compared to the reference method of analysis for Trazodone Hydrochloride and no significant differences were found.


索引于

  • 中国社会科学院
  • 谷歌学术
  • 打开 J 门
  • 中国知网(CNKI)
  • 引用因子
  • 宇宙IF
  • 研究期刊索引目录 (DRJI)
  • 秘密搜索引擎实验室
  • 学术文章影响因子(SAJI))
  • ICMJE

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