抽象的

Plasma microRNAs are promising biomarkers for maxillary deficiency

Qing Wang, Ying Cai, Fengshan Chen


Objects: Recently, plasmamicroRNAs (miRNAs) emerging as newpotential molecular biomarkers in various fields of research and have significant effects in disease formation. In this study, we hypothesized that plasma miRNAs may play an important role in maxillary deficiency (MD), and would be excellent biomarkers for this disease. Methods: Two cohorts were examined in this study. Cohort one comprised three MD cases and three controls with normal Class I occlusion. Cohort two comprised 31 cases and 31 controls. We first used a microarray assay to examine the miRNA expression profiles in cohort one to identify candidate miRNAs. Secondly, the candidate miRNAs were validated by qRT-PCR in cohort two. Finally, ROC analysis was performed to identify potential biomarkers inMD diagnosis. Results: Themicroarray assay identified sevenmiRNAs with a p-value < 0.05; in which those showing a fold change > 2 were chosen as candidate disease biomarkers. At the validation stage, miR- 4505 was showing a satisfactory diagnostic capacity, with an AUC of 0.844 and sensitivity and specificity of 84.0% and 71.2%, respectively. Conclusion: Plasma miRNAs are associated with MD and may be useful biomarkers forMDearly diagnosis and assistant inMD linicalmanagement.


索引于

  • 中国社会科学院
  • 谷歌学术
  • 打开 J 门
  • 中国知网(CNKI)
  • 引用因子
  • 宇宙IF
  • 研究期刊索引目录 (DRJI)
  • 秘密搜索引擎实验室
  • 学术文章影响因子(SAJI))
  • ICMJE

查看更多

期刊国际标准号

期刊 h 指数

Flyer