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Quantitative determination of tiaprofenic acid by visible spectrophotometry using diazotization and coupling reactions

K.Raghubabu, N.Mohan, B.Kalyana Ramu

A simple and sensitive visible spectrophotometric method for the determination of tiaprofenic acid in pure and dosage forms based on the formation of colored azodye under specified experimental conditions are described. The colored species exhibits absorption maxima at 470nm. Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges 5-25 µg/ml. The proposed method is applied to commercial available tablets and the results are statistically compared with those obtained by the UV reference method and validated by recovery studies. The results are found satisfactory and reproducible. This method is applied successfully for the estimation of the tiaprofenic acid in the presence of other ingredients that are usually present in dosage forms. The method offers the advantages of rapidity, simplicity and sensitivity and normal cost and can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents.