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Simultaneous Spectrophotometric Estimation of Ezetimibe and Atorvastatin in Pharmaceutical Dosage Form

P. H. Sakpal, M. N. Deodhar, V. P. Ghodse, B. A. Agarwal, R. H. Khiste, R. A. Sonawane and P. L. Ingale

One simple, sensitive, accurate, precise, rapid and economical method is developed for the estimation of ezetimibe and atorvastatin in two components solid dosage form. The method is based on area under curve method. Ezetimibe has absorbance maxima at 232.5 nm and atorvastatin has absorbance maxima at 246.5 nm in methanol. The linearity was obtained in the concentration range 5-30 μg/mL for both ezetimibe and atorvastatin. In this method, the concentrations of the drugs were determined by using area under curve method. Concentration of the drugs were determined by using range of wavelengths at 230-235 nm and 244-249 nm for atorvastatin and ezetimibe in methanol. The results of analysis have been validated statistically and by recovery studies.