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Simultaneous spectroscopic determination of tinidazole and clotrimazole from combined dosage forms from pharmaceutical formulations

Pasham Venkteshwalu, A.Bhanu Prasad

A new spectroscopic method for the simultaneous and separate estimation of Tinidazole and Clotrimazole in the binary tablet formulations has been described. The method is based on the estimation of the one drug in presence of another drug by absorbance difference method. The Tinidazole and Clotrimazole solutions were scanned over the range 200 to 315 nm. In this method, twowavelengths 240 nmand 285 nmwere selected for Tinidazole. At these wavelengths the absorbance is almost zero and in case of Clotrimazole there should be considerable absorbance difference. Similarly, the two wavelengths 200 nmand 235 nmwere selected for Clotrimazole; at these two-wavelengths difference is almost zero and there should be considerable absorbance difference in case of Tinidazole. In the Tinidazole and Clotrimazole solution the absorbance values of four wavelengths 240,285,200 and 235 nmweremeasured. The amount of Clotrimazole is directly proportional to the absorbance difference 200 and 235 nm. Similarly, the amount of Tinidazole is directly proportional to the absorbance difference between 240 and 285 nm.