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Spectrophotometric estimation of gabapentin in bulk and capsule formulation

J.N.Sangshetti, P.R.Mahaparle, V.P.Rane, D.B.Shinde

A simple sensitive, rapid spectrophotometric method for the determination of gabapentin(GBP) in bulk and formulation is described. Themethod is based based on reaction of drug with ferric chloride in presence of potassium ferricyanide. The bluish green coloured chromogen formed has absorption maxima at 746nm. Beer’s law was followed in the concentration range of 2 to 16g/ml. The proposed method is useful, accurate, reproducible for the routine estimation of GBP in bulk and capsule.