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Spectrophotometric Estimation of Granisetron in Bulk and Tablet Formulation

S. Angayer Kanchana, Ajithadas Aruna, V. Niraimathi and A. Jerad Suresh

Three simple, precise and economical spectrophotometric methods have been developed for the estimation of granisetron in bulk and pharmaceutical preparations. Method A involves the determination of granisetron by dissolving in distilled water and followed by measuring the absorbance at 301 nm. Method B involves the derivatisation of the primary spectra to the second order. The drug obeyed Beer’s law in the concentration range of 5-50 µg/mL for both the methods. Method C is based on the reaction of granisetron with ferric chloride and 1,10-phenanthroline to form blood red coloured chromogen and followed by measuring the absorbance at 510 nm. The results of the analysis were validated statistically and found to be satisfactory.