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Spectrophotometric Estimation of Pantoprazole in Tablet Dosage Form

Shamkant S. Patil, P. N. Dhabale and B. S. Kuchekar

Three simple, precise and economical UV methods have been developed for the estimation of pantoprazole in bulk and pharmaceutical formulations. Pantoprazole has the absorbance maxima at 290 nm (Method A) and in the first order derivative spectra, showed zero crossing at 290 nm, with a sharp peak at 282 nm when n=1 (Method B), Method C applied was Area Under Curve (AUC) for analysis of pantoprazole in the wavelength range of 286-296 nm. Drug followed the Beer’s Lamberts range of 5-35, 10-100, 5-40 ;g/mL for the Method A, B and C, respectively. Results of analysis were validated statistically and by recovery studies and were found to be satisfactory.