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Synthesis and Antibacterial Activity of 2-Substituted Benzimidazole-1-carbodithioate

V. P. Devmurari, Shivanand Pandey, N. G. Thummar, A. K. Gajjar and N. P. Jivani

A series of methyl 2-substituted benzimidazole-1-carbodithioates was successfully synthesized. Benzimidazoles were prepared by condensation of o-phenylenediamine with substituted carboxylic acid and by condensation of substituted benzaldehydes, sodium metabisulphate and o-phenylenediamine. Methyl carbodithioate derivatives of the benzimidazole were prepared by reaction with carbon disulfide. In vitro antibacterial activity of the synthesized compounds was analyzed against three gram-positive bacterial species and gram negative microorganism by agar well-diffusion method (Cup plate method).