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Synthesis and Anti-HIV Activity of Some Novel 2, 3-Disubstituted Quinazolin-4(3H)-Ones

P. Selvam, D. Sridharan, N. Murugesh, M. Chandramohan and M. Xwiturouw

Three of novel 2, 3-disubstituted quinazolin-4(3H)-one derivatives, have been synthesized by condensation of 2-substituted benzo[1,3]oxazine-4-ones and primaquine. Their chemical structures were assigned by means of spectral analysis (FT-IR, 1H - NMR, MS). Synthesized compounds were screened for in vitro antiviral activity against HIV-1 in MT-4 cells. Compound 6-bromo-3-(4-(6-methoxyquinolin- 8-ylamino)pentyl)-2-phenylquinazolin-4(3H)-one (PY-QZ MBR) exhibited 15 percent maximum protection against replication of HIV-1 (IIIB) in acutely infected MT-4 cells .