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Synthesis and biological evaluation of novel pyridone derivatives as cardio tonic agents

S.N.Mamledesai, Shakti P.Singh, Navin C.Patel

Two derivatives of 3-acetyl-4-amino-3,4-dihydropyridin-2(1H)-one and 3- acetyl-3,4-dihydro-4-(phenylamino)pyridin-2(1H)-onewere prepared by reaction of enamine and diethyl malonate and tested for cardio tonic activity by isolated frog heart perfusion technique will be used as a model to evaluate the activity of various synthesized 2-pyridone derivatives in different concentration and anti-hypertensive activitywas done by the tail cuffmethod in albino rats. The basal cardiac contraction will be recorded on a kymograph after the administration of calcium free Ringer solution. The cardiac activity in terms of heart rate (HR) and height of force of contraction (HFR) will be recorded. These two compounds showed good activity as compared to the standard drugs.