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Synthesis and Characterization of Novel Thiadiazole and Thiazolidinone Incorporated Dihydropyrimidine Derivatives

Alka Agarwal, D. Bele and I. J. Singhvi

In the present study, a novel series of thiadiazole and thiazolidinone incorporated dihydropyrimidine derivatives were synthesized by treating Substituted aldehyde with ethylacetoacetate and urea to yield pyrimidine derivatives (1), which on reaction with thiosemicarbazide followed by cyclization incorporated aminothiadiazole ring (3). Compound (3) reacted with benzaldehyde to give Shiff bases (4) followed by reaction with thioglycollic acid to give title compound. The structures of all synthesized compounds were characterized by melting point determination, TLC, elemental analysis, IR, 1 H NMR, 13C-NMR and LCMS.