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Synthesis, Characterization and Pharmacological Evaluation of Some Novel 2,5-Disubstituted-1,3,4-Thiadiazole Derivatives

Tanveer Ahmad and Arvind Kumar Singh

2,5-disubstituted-1,3,4-thiadiazole derivatives have been synthesized with different substituted aromatic acid. Esterification of aromatic acid with ethanol followed by hydrazination, salt formation and cyclization to formed 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-thiol, 5-(3-chlorophenyl)-1,3,4-thiadiazole-2- thiol, 5-(2-nitrophenyl)-1,3,4-thiadiazole-2-thiol and 5-(4-nitrophenyl)-1,3,4-thiadiazole-2-thiol. All the new compounds were confirmed by IR, NMR and mass spectral analysis. These compounds were evaluated for their antibacterial and anti-inflammatory activity.