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Synthesis, DNA binding and cleavage studies of Cr(III) complexes of chromeno[2,3-b]quinoline and 1,10 phenanthroline

C.N.Sudhamani, H.S.Bhojya Naik, M.C.Prabhakara


The new complexes of the type [Cr(CQ)3](PF6)3 (1) and [Cr(phen)2(CQ)](PF6)3 (2) (where CQ=chromeno(2,3- b)quinoline, phen=1,10-phenanthroline) were synthesized and structurally characterized. Binding of these complexes with(ds) DNAwere analyzed by absorption spectra, viscosity, thermal denaturation and cyclic voltammetric studies. Detailed analysis revealed that both the metal complexes intercalates into the DNA base stack with CQ as intercalator. The oxidative cleavage activities of the complexes (1) and (2) were studied with supercoiled (SC) pUC19 DNA by using gel electrophoresis, and they show nuclease activity.


索引于

  • 中国社会科学院
  • 谷歌学术
  • 打开 J 门
  • 中国知网(CNKI)
  • 引用因子
  • 宇宙IF
  • 米亚尔
  • 秘密搜索引擎实验室
  • 欧洲酒吧
  • 巴塞罗那大学
  • ICMJE

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