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Synthesis of potential antibacterial and antifungal agents:n-(5-(2-chlorobenzylidene)-4-oxo-2-arylthiazolidin-3-yl)-2- (6-methoxy-naphthalen-2-yl) propanamide

A.P.Zala, V.D.Dave, N.K.Undavia

Synthesis of few N-(5-(2-Cholrobenzylidene)-4-oxo-2-arylthiazolidine- 3-yl)-2-(6-methoxynephthalen-2-yl) propanamide was planned on account of the potential nature of Naproxen as analgesic and anti-inflammatory agents. N-(5-(2-Cholrobenzylidene)-4-oxo-2-arylthiazolidine-3-yl)-2-(6- methoxy-nephthalen-2-yl)propanamide are prepared by condensation of 2-(6-methoxynephthalen-2-yl) -N-(4-oxo-2-aryl thiazol idin-3- yl)propanamide with 2-chlorobenzaldehyde in presence of strong base sodium ethoxide. The structures of these compounds have been established on the basis elemental analysis and spectral data. All the synthesized compounds were tested for their anti-bacterial and anti-fungal activities. Some of the synthesized compounds have shown excellent antibacterial and anti-fungal activities.