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Synthesis of unsymmetrical triindolylmethanes as potent analgesic agents

A.J.Yamuna, K.M.Mahadevan, P.V.Habbu, V.P.Vaidya

Various unsymmetrical triindolylmethanes were synthesized by multistep approach. In final step the targeted synthesis was carried out by the condensation of twomoles of simple indolewith previously prepared ethyl 3-formylindole- 2-caboxylates in presence of antimony trichloride as catalyst. The pharmacological screening of the obtained compounds was proved for their potent analgesic activity.